詹明賢 助理教授

學歷
國立臺灣大學　化學系　博士

研究專長
奈米技術、核醫材料、生物醫學影像檢測與應用

學歷
2014 Sep. – 2018 Jun. 國立臺灣大學　化學系 博士
2012 Sep. – 2014 Jun. 國立海洋大學　生命科學暨生物科技學系 碩士
2008 Sep. – 2012 Jun. 國立海洋大學　生命科學暨生物科技學系 學士

經歷
2018 Aug. – 2023 Jan. 中央研究院　基因體研究中心 博士後研究學者
2023 Feb. – Present 國立陽明交通大學　生物醫學影像暨放射科學系　助理教授

實驗室網站

研究專長

  • 奈米技術
    在近原子尺度上操縱物質以產生新的結構、材料和設備。該技術有望在許多領域取得科學進步，例如醫藥、消費品、能源、材料和製造。
    Organic nanomaterials: Micelles, Liposomes, Dendrimers…
    Inorganic nanomaterials: Carbon nanotubes, Metallic particles, Quantum dots…
  • 核醫材料
    核醫材料可用於診斷和治療疾病，透過核醫程序加載放射性藥物之核醫材料可治療包括甲狀腺功能亢進症、癌症、淋巴瘤等常見人類疾病。
  • 生物醫學影像檢測
    醫療行業中生物成像的示例包括X射線(X-ray)與超音波(ultrasound)圖譜、磁共振造影(Magnetic Resonance Imaging, MRI)、3D與4D生物光學圖像(Optical Imaging, OI)、電腦斷層掃描(Computed Tomography, CT)與正電子放射斷層攝影(Positron Emission Tomography, PET)等。
  • 生醫材料應用
    泛指具有生物相容性而可被應用於活體的天然或人工合成材料，依材料性質可分為金屬、陶瓷、高分子有機聚合體以及複合性材料等四類。本實驗室主要研究目標即開發新穎生醫材料應用於癌症早期診斷與治療、腦神經科學研究及探討材料之生物累積與潛在毒性。

榮譽記錄

2018 榮譽會員 斐陶斐協會榮譽會員
2020 中央研究院博士後研究學者 中央研究院
2020 優秀論文獎 肝病防治學術基金會
2021 優秀研發替代役人員 內政部役政署研發替代役

學術著作

期刊論文

  1. M. H. Chan and H. M. Lin*, “Preparation and Identification of Multifunctional Mesoporous Silica Nanoparticles for in vitro and in vivo Dual-Mode Imaging, Theranostics, and Targeted Tracking.” Biomaterials, 2015, 46, 149–158.
  2. M. H. Chan, C. W. Chen, I. J. Lee, Y. C. Chan, D. Tu, M. Hsiao*, C. H. Chen, X. Chen, and R. S. Liu*, “Near-Infrared Light-Mediated Photodynamic Therapy Nanoplatform by the Electrostatic Assembly of Upconversion Nanoparticles with Graphitic Carbon Nitride Quantum Dots.” Inorg. Chem., 2016, 55, 10267–10277.
  3. M. H. Chan, Y. T. Pan, I. J. Lee, C. W. Chen, Y. C. Chan, M. Hsiao*, F. Wang, L. Sun, X. Chen, and R. S. Liu*, “Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light.” Small, 2017, 13, 1770038.
  4. M. H. Chan and R. S. Liu*, “Advanced Sensing, Imaging, and Therapy Nanoplatforms Based on Nd3+-doped Nanoparticle Composites Exhibiting Upconversion Induced by 808 nm Near-Infrared Light.” Nanoscale, 2017, 9, 18153–18168.
  5. M. H. Chan, S. P. Chen, C. W. Chen, Y. C. Chan, R. J. Lin, D. P. Tsai, M. Hsiao*, R. J. Chung*, and R. S. Liu*, “Single 808 nm Laser Treatment Comprising Photothermal and Photodynamic Therapies by using Gold Nanorods Hybrid Upconversion Particles.” J. Phys. Chem. C, 2018, 122, 2402–2412.
  6. M. H. Chan, Y. T. Pan, Y. C. Chan, M. Hsiao*, C. H. Chen, L. Sun, and R. S. Liu*, “Nanobubble-Embedded Inorganic Nanocomposites for Tumorous Multiple Imaging and Treatment.” Chem. Sci., 2018, 9, 3141–3151.
  7. L. E. Andrews#, M. H. Chan#, and R. S. Liu*, “Nano-lipospheres as Acoustically Active Ultrasound Contrast Agents: Evolving Tumor Imaging and Therapy Technique.” Nanotechnology, 2019, 30, 182001.
  8. M. H. Chan, C. Y. Lai, Y. C. Chan, M. Hsiao*, R. J. Chung*, X. Chen, and R. S. Liu*, “Development of Upconversion Nanoparticle-Conjugated Indium Phosphide Quantum Dots for MMP2 Cancer Transformation Sensing.” Nanomedicine, 2019, 14, 1791–1804.
  9. M. H. Chan, R. S. Liu*, and M. Hsiao*, “Graphitic Carbon Nitride-Based Nanocomposites and Their Biological Applications: A Review.” Nanoscale, 2019, 11, 14993–15003.
  10. W. T. Huang#, M. H. Chan#, X. Chen, M. Hsiao*, and R. S. Liu*, “A Theranostic Nanobubble Encapsulating a Plasmonic-Enhanced Upconversion Hybrid Nanosystem for Targeted Cancer Therapy.” Theranostics, 2020, 10, 782–796.
  11. M. H. Chan, M. R. Hsieh, R. S. Liu*, D. H. Wei*, and M. Hsiao*, “Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy.” Chem. Mater., 2020, 32, 697–708.
  12. M. H. Chan, W. T. Huang, J. Wang, R. S. Liu, and M. Hsiao*. “Next Generation Cancer-Specific Hybrid Theranostic Nanomaterials: MAGE-A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for in-situ Suppression of Lung Adenocarcinoma Growth and Distal Metastasis.” Adv. Sci., 2020, 7, 1903741.
  13. M. H. Chan, Y. C. Chan, R. S. Liu*, and M. Hsiao*, “A Selective Drug Delivery System Based on Phospholipid-Type Nanobubbles for Lung Cancer Therapy.” Nanomedicine, 2020, 15, 2689–2705.
  14. C. L. Cheng#, M. H. Chan#, S. J. Feng, M. Hsiao*, and R. S. Liu*, “Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites.” ACS Appl. Mater. Interfaces, 2021, 13, 6099–6108.
  15. M. H. Chan#, W. Chen#, C. H. Li, C. Y. Fang, Y. C. Chang, D. H. Wei, R. S. Liu*, and M. Hsiao*, “An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood−Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles.” ACS Appl. Mater. Interfaces, 2021, 13, 26759–26769.
  16. Y. C. Chang#, M. H. Chan#, C. H. Li, C. Y. Fang, M. Hsiao*, and C. L. Chen, “Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers.” Biomedicines, 2021, 9, 931.
  17. M. H. Chan#, C. N. Lu#, Y. L. Chung, Y. C. Chang, C. H. Li, C. L. Chen*, D. H. Wei*, and M. Hsiao, “Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment.” J. Nanobiotechnology, 2021, 19, 308.
  18. M. H. Chan#, B. G. Chen#, L. T. Ngo, W. T. Huang, C. H. Li, R. S. Liu*, and M. Hsiao*, “Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application.” Pharmaceutics, 2021, 13, 1874.
  19. Z. X. Chang, C. H. Li, Y. C. Chang, C. Y. F. Huang, M. H. Chan*, and M. Hsiao*, “Novel monodisperse FePt nanocomposites for T2-weighted magnetic resonance imaging: biomedical theranostics applications.” Nanoscale Adv., 2022, 4, 377–386.
  20. M. H. Chan#, Z. X. Chang#, C. Y. F. Huang, L. James Lee, R. S. Liu*, and M. Hsiao*, “Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment.” Nanoscale Horiz., 2022, 7, 352–367.
  21. M. H. Chan, W. T. Huang, A. Satapathy, T. Y. Su, M. Hsiao*, and R. S. Liu*, “Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics.” Pharmaceutics, 2021, 14, 456.
  22. M. H. Chan, W. T. Huang, K. C. Chen, T. Y. Su, Y. C. Chan, R. S. Liu*, and M. Hsiao*, “The optical research progress of nanophosphors composed of transition elements in the fourth period of near-infrared windows I and II for deep-tissue theranostics.” Nanoscale, 2022, 14, 7123–7136.
  23. C. H. Li, Y. C. Chang, M. Hsiao*, and M. H. Chan*, “Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities.” Pharmaceutics, 2022, 14, 1282.

研討會論文

  1. M. H. Chan, Y. C. Chan, R. S. Liu*, and M. Hsiao*. Near-Infrared Light Mediated Photodynamic Therapy by Upconversion Nanoparticles with Graphitic Carbon Nitride Quantum Dots. 4th NanoMed Conference, Nov. 7 to 9, 2016, Warsaw, Poland.
  2. M. H. Chan, C. W. Chen, I. J. Lee, Y. T. Pan, Y. C. Chan, M. Hsiao*, and R. S. Liu*. Near-Infrared Light Mediated Photodynamic Therapy by Upconversion Nanoparticles with Graphitic Carbon Nitride Quantum Dots. Annual Meeting of Chemical Society, Dec. 3 to 4, 2016, Taichung, Taiwan. (Poster awards)
  3. M. H. Chan, C. Y. Lai, W. T. Huang, L. E. Andrew, Y. C. Chan, M. Hsiao*, and R. S. Liu*. Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light. Annual Meeting of Chemical Society, Dec. 1 to 2, 2017, Chiayi, Taiwan.
  4. M. H. Chan, R. S. Liu*, and M. Hsiao*. A Theranostic Nanobubble Encapsulating a Drug Assistant Upconversion Hybrid Nanosystem for Targeted Lung Cancer Therapy. Drug Discovery Conference, Dec. 3 to 5, 2018, San Francisco, CA, USA.
  5. M. H. Chan, R. S. Liu*, and M. Hsiao*. Highly specific tumor-targeting near-infrared persistent luminescence nanomaterials (ZGO and LGGO) for lung cancer bioimaging. American Association for Cancer Research (AACR) Annual Meeting, Mar. 29 to Apr. 3, 2019, Atlanta, GA, USA. (Cancer Res., 2019, 13, S1943)
  6. M. H. Chan and M. Hsiao*. Light/Ultrasound Responsive 750 nm-Emitted InP Quantum Dots Hybrid Nanobubble for Brain Tumor Imaging, American Society for Investigative Pathology (ASIP) Annual Meeting, Apr. 6 to 9, 2019, Orlando, FL, USA. (FASEB J., 2019, 33, 1_662.6)
  7. M. H. Chan, R. S. Liu, and M. Hsiao*. Anchor targeting ligands, inorganic nanocomposites, and loads drug in nanobubbles for liver tumor photo/chemotherapy. American Society for Investigative Pathology (ASIP) Annual Meeting, Apr. 6 to 9, 2019, Orlando, FL, USA. (FASEB J., 2019, 33, 1_496.5)
  8. M. H. Chan, L. J. Lee, and M. Hsiao*. Exosome-Encapsulated Persistent Luminescence Nanoparticles Enabled Medicinal Product-Based Drug Delivery System, American Society for Investigative Pathology (ASIP) Annual Meeting, Apr. 4 to 7, 2020, San Diego, CA, USA. (FASEB J., 2020, 34, 1-1)
  9. M. H. Chan and M. Hsiao*. Upconversion Nanoparticles Induce Lung Inflammatory, Immunologic and Pulmonary Injury in Vivo, American Society for Investigative Pathology (ASIP) Annual Meeting, Apr. 4 to 7, 2020, San Diego, CA, USA. (FASEB J., 2020, 34, 1-1)

專書

  1. M. H. Chan and R. S. Liu*, 2016, “Phosphors, Upconversion Nano Particles, Quantum Dots, and Their Applications, Volume 2, Chapter 38: Carbon Nitride Quantum Dots and Their Applications” Springer-Verlag Berlin Heidelberg.
  2. M. H. Chan, W. T. Huang, M. Hsiao, and R. S. Liu*, 2022, “Phosphor Handbook, Chapter 10: Design Growth of Nanophosphors and Their Applications” Taylor & Francis Group.

專利刊登

中華民國專利

類別專利名稱國別專利號碼發明人專利公告日期
發明毛髮生長組合物
及其製造方法		中華
民國		I571260林秀美、詹明賢、呂祐丞、張宗元、
顏兆男、陳柏鈞、劉聿、陳偉江、
蕭淑敏、簡芷筠、郭晉傑		2017/02/21
發明以生物性原料製備螢光粉
主體材料的方法		中華
民國		I558790林秀美、張宗元、陳偉江、周伯峰、
顏兆男、陳柏鈞、許嘉珊、劉聿、
詹明賢、呂祐丞、蕭淑敏		2016/11/21
發明奈米複合材料及其用途中華
民國		202108183蕭宏昇、詹明賢、蘇比、謝明哲、
包真、王安邦、劉如熹		2021/03/01
發明微反應器及其使用方法中華
民國		202109035蕭宏昇、謝明哲、包真、詹明賢、
劉如熹、王安邦、瞿嘉志		2021/03/01

美國專利

TypeNameCountryNo.InventorsDate
InventionNanocomposite particle and uses thereofUSAWO2021042082A1Michael Hsiao, Ming-Hsien Chan, Nelson G. Chen, Ru-Shi LiuMar. 4, 2021
InventionNanocomposite and uses thereofUSAWO2021021866A1Michael Hsiao, Ming-Hsien Chan, Subbiramaniyan Kubendhiran, Ming-Che Hsieh, Zhen Bao, An-Bang Wang, Ru-Shi LiuFeb. 4, 2021
InventionMicro-reactor and method of useUSAWO2021026176A1Michael Hsiao, Ming-Che Hsieh, Zhen Bao, Ming-Hsien Chan, Ru-Shi Liu, An-Bang Wang, Chia-Chih ChuApr. 5, 2012

聯絡資訊

辦公室：生醫工程館研究大樓 461室／電話：(02) 2826-7000 #67302 (Office)

電子信箱：mhchan@nycu.edu.tw

諮詢時間：每週四14:00 ~ 16:00

個人網站：核醫與奈米材料實驗室

實驗室：(02) 2826-7000 #65968 (Laboratory)