楊逢羿 特聘教授

台灣大學 醫學工程學博士
專長：
醫用超音波、醫學影像整合應用、腦科學研究、醫學工程、神經調控轉譯醫學

醫用超音波暨醫學影像整合應用實驗室

新創獎官方網站技術介紹頁面，網址：https://reurl.cc/p6WMnd

學歷

  • 國立台灣大學醫學工程學研究所博士　　　　2004 ~ 2007
  • 國立陽明大學醫學工程研究所碩士　　　　　1995 ~ 1997
  • 國立交通大學電機工程學系學士　　　　　　1989 ~ 1993

經歷

  • 國立陽明交通大學生物醫學影像暨放射科學系  系主任   2021~迄今
  • 國立陽明大學生物醫學影像暨放射科學系 特聘教授 2019~迄今
  • 國立陽明大學生物醫學影像暨放射科學系 教授 2014~2019
  • 國立陽明大學生物醫學影像暨放射科學系 副教授 2011~ 2014
  • 國立陽明大學生物醫學影像暨放射科學系 助理教授 2008~ 2011
  • 明基三豐醫療器材股份有限公司 研發部經理 2007
  • 行政院衛生福利部食品藥物管理署 薦任技士 2003~ 2004
  • 台積電 資深工程師 1997~ 2003

證照

  • 公務人員醫學工程科高考及格
  • 輻射安全證書

榮譽記錄

  • 2021-2023國立陽明大學學術卓越獎勵
  • 2020榮總台灣聯合大學合作研究優良論文獎
  • 2020國立陽明大學45周年校慶「5大創新」
  • 2019-2022國立陽明大學特聘教授
  • 2019-2021國立陽明大學學術卓越獎勵
  • 2018科技部未來科技突破獎
  • 2018榮總台灣聯合大學合作研究優良論文獎
  • 2017-2019國立陽明大學學術卓越獎勵
  • 2015-2017國立陽明大學學術卓越獎勵
  • 2014榮總台灣聯合大學合作研究優良論文獎
  • 2013-2015國立陽明大學學術卓越獎勵
  • 2013中央研究院年輕學者研究著作獎
  • 2013-2016科技部優秀年輕學者研究計畫
  • 2012第九屆國家新創獎
  • 2011-2013國立陽明大學學術卓越獎勵
  • 2010-2011國立陽明大學傑出學術研究出版獎勵
  • 2010國科會補助大專校院特殊優秀人才

研究興趣:

 穿顱超音波刺激治療神經退化性疾病 – 以失智症為例

世界各國人口老化趨勢嚴重，失智症風暴席捲全球。失智症是一種疾病，可分為退化性與血管性兩大類，其中最常見的是阿茲海默症，大約佔老人失智五成的比例，是一種持續性神經功能障礙，病患會逐漸喪失記憶，並且有語言和情緒上的障礙。另一為血管性失智症，約佔三成，是因腦中風或慢性腦血管病變，導致腦部血液循環不良，造成腦細胞死亡與智力衰退，為引發失智症的第二大原因。

2015年8月國際失智症協會（World Dementia Council）發布的全球失智症報告，全球失智症人口約4680萬人，一年平均新增990萬名病患，平均每3秒就有1人。預估到2030年，全球失智人數將增至7470萬人；2050年失智症人數恐將高達1億3150萬人。 快速走向超高齡社會的台灣，同樣深陷失智風暴中。台灣失智症協會推估目前每年台灣每天約新增25例失智症者，至130年預計將達到最高峰、每天約新增63名（即該年新增約達23000人）。未來政府及民間都應積極準備迎接失智盛行世代的來臨。

目前並無有效根治失智症的方法，臨床上主要以藥物減緩其惡化；常見者為乙醯膽醶抑制劑及阻斷神經細胞損傷的NMDA受體拮抗劑這兩大類藥品。全球新藥研發的速度推陳出新，已有幾種失智症的新藥正在臨床實驗中。然而，失智症患者被診斷時，腦部功能通常都已損害很多年，即使新藥有療效，已發病的病人也不可能被新藥治癒且藥物常伴隨著副作用。近年來，非藥物治療法逐漸興起，神經學家開始應用許多外在電、磁或光刺激模式來調控中樞神經之興奮性，應用於失智症相關疾病研究，但是其作用機制仍多屬未知。最近，本人在陽明大學所組成治療用超音波研究團隊，在腦部治療用超音波領域研究多年後，有了嶄新突破性的失智症治療技術開發！

近年由本人所帶領的神經退化性疾病研究團隊經過累積多年治療用超音波應用於腦部疾病治療之研究經驗，全球首創利用能夠穿過頭骨且適當參數的低強度脈衝式超音波刺激腦部，使其增加內生性的腦源性神經滋養因子(brain-derived neurotrophic factor, BDNF)，以達到預防與治療失智症之目的。相較於藥物治療能夠免除其藥物的副作用，提供安全且創新之腦部神經退化性疾病之非侵入式物理療法，目前針對鋁誘導阿茲海默症與缺血性失智症動物模型進行臨床前動物實驗，結果證實超音波刺激不但可以恢復失智症實驗鼠的學習記憶功能，並且減少實驗鼠腦部神經細胞的死亡。

超音波目標藥物傳輸 – 非侵入式局部開啟血腦障壁

治療用超音波(Therapeutic Ultrasound)目前已成為一個新興潛力的研究領域，其原理是利用非侵入方式將高強度聚焦超音波(High Intensity Focused Ultrasound)能量導入所需治療之區域，利用組織對機械波能量之吸收造成溫昇，將該區域之溫度提昇到43℃~45℃之間或利用高強度機械波壓力產生空穴化作用，產生高溫及高壓對組織進行破壞等現象來去除或治療腫瘤。

此外，前人的研究指出聚焦式超音波結合超音波顯影劑能以非侵入方式將特定區域的血腦屏障暫時開啟。本實驗室研究是探討超音波顯影劑濃度與超音波聲壓力對局部開啟血腦屏障後治療效果與藥物動力學分析。由Evans blue在腦組織的滲出量得知，在相同的聲壓力下高濃度的顯影劑可造成較高的Evans blue的滲出量，而當顯影劑濃度相同時，較高的聲壓力也可以得到類似的結果。此外，在高濃度的顯影劑下，可以使血腦屏障的開啟較集中於焦點區域。從組織切片觀察得知，在適當的低濃度顯影劑時，可以在不傷害正常腦組織的情況下將血腦屏障開啟，然而在高濃度時會造成細胞凋亡的現象而其凋亡數量隨著距離焦點位置的增加而遞減。此研究驗證適當的顯影劑濃度能在不傷害正常腦組織的情況下增強穿顱式超音波將血腦屏障開啟的效率並且更集中於焦點區域。此種超音波藥物目標區域傳輸系統的原理是超音波的機械波與打入病患血管內的微氣泡相互作用所產生的空穴化效應，促使在超音波施打區域的血管通透性增加，達到只有在病灶區域的藥物濃度提昇，進一步提高治療效果。同時，因為能降低病患治療藥物的施打劑量，相對減少了藥物引發其他副作用的可能性。研究開發以磁振造影導引暨監控聚焦超音波開啟血腦障壁與藥物釋放系統，以超音波將治療藥物導引至局部的治療目標區域並增強病灶區域的藥物傳輸量，提高治療效果與治癒率並且以核醫影像做藥物動力學分析。

目前本實驗室已開發的「超音波藥物傳輸監測裝置」技術，適用於各種組織器官。其原理是以都卜勒超音波量測脈衝聚焦式超音波施打血管位置前後之血流速度，除了可以確認施打位置的正確性外，更可由計算而得之收縮期峰值血流速度(peak systolic velocity, PSV) 和搏動指數(pulsatility index, PI)來間接即時監測超音波施打目標區域的藥物滲透量。此關鍵技術及監控軟體可相容於現有各大廠牌超音波系統，未來市場規模潛力極大。另外，將超音波熱療結合放射治療系統之開發亦為本實驗室之研究方向。

研究計畫:

  1. 正子影像評估超音波刺激對思覺失調症動物模型腦內多巴胺之影響 (亞陽研究計畫112DN27)
  2. 腹部超音波刺激透過腸腦軸對炎症性腸病與腦部炎症疾病的神經調控作用與機制探討 (國科會NSTC 111-2218-E-A49-033-MY3)
  3. 低強度超音波刺激腸道發炎之腹部以減緩腸腦發炎反應之作用與機制探討 (國科會NSTC 111-2314-B-A49-045-MY3)
  4. 超音波刺激逆轉思覺失調症腦中蛋白質異常之研究 (亞陽研究計畫111DN27)
  5. 動態對比磁振造影分析超音波對腦中風血管通透性之影響 (振陽研究計畫CY11113)
  6. 超音波神經調控運用於多發性硬化症治療之作用及機轉探討    (科技部MOST 110-2314-B-A49A-502-MY3)
  7. 穿顱超音波刺激治療思覺失調症之作用探討(亞陽研究計畫110DN33)
  8. 穿顱超音波刺激於腦中風病患的可行性試驗 (振陽研究計畫CY11006)
  9. 穿顱超音波刺激於阿茲海默病患的可行性試驗與系統開發II(科技部育苗計畫MOST 109-2321-B-010-004-)
  10. 超音波改善腦損傷與其長期行為之機制探討 (振陽研究計畫CY10927)
  11. 穿顱超音波刺激運用於阿茲海默症治療之作用及機轉探討(科技部MOST 108-2314-B-010-034-MY3)
  12. 穿顱超音波刺激於阿茲海默病患的可行性試驗與系統開發I(科技部育苗計畫MOST 108-2321-B-010-005-)
  13. 超音波減緩腦損傷神經退化與細胞凋亡之研究 (振陽研究計畫CY10833)
  14. 低強度脈衝式超音波應用於創傷性腦損傷動物模型治療之評估 (榮台聯大VGHUST107-G7-3-1)
  15. 超音波增加腦源性神經滋養因子及減緩腦損傷之研究 (振陽研究計畫CY10721)
  16. 低強度脈衝式超音波運用於思覺失調症治療之作用及機轉探討 (科技部MOST 106-2221-E-010-004-MY3)
  17. 低強度脈衝式超音波運用於缺血性腦中風預防和復發防治之作用及機轉探討(2) (科技部MOST 106-2314-B-002-018)
  18. 低強度超音波對脂多醣誘導阿茲海默症動物模式中記憶缺損治療效果之研究 (榮台聯大VGHUST106-G7-6-1)
  19. 超音波調控血腦屏障通透性及減緩腦水腫之研究 (振陽研究計畫CY10622)
  20. 低強度脈衝式超音波應用於創傷性腦損傷治療之探討 (科技部MOST 105-2221-E-010-003)
  21. 低強度脈衝式超音波運用於缺血性腦中風預防和復發防治之作用及機轉探討 (科技部MOST 105-2314-B-002-013)
  22. 萌芽創業推廣計畫 (科技部萌芽計畫104年度陽明萌芽功能中心)
  23. 低強度脈衝式超音波刺激腦部神經滋養因子分泌之研究 (科技部MOST 104-2314-B-010-003-MY3)
  24. 低強度脈衝式超音波促進創傷後壓力症候群腦部神經滋養因子之表現 (振陽研究計畫CY10418)
  25. 低強度超音波治療創傷後壓力症候群之研究 (榮台聯大VGHUST104-G7-6-1)
  26. SPARK生醫與醫材轉譯加值人才培訓計畫 (科技部SiiC 103年度 SPARK-YM)
  27. 低強度聚焦式超音波神經調節用於控制癲癇的發作 (振陽研究計畫103F003C17)
  28. 動態對比磁振造影即時監控聚焦式超音波局部開啟大鼠血腦障壁後之藥物動力學分析 (國科會NSC 102-2221-E-010-005-MY3)
  29. 聚焦式超音波開啟血腦屏壁後111In-標靶藥物於腦腫瘤之藥物動力學分析 (振陽研究計畫102F218C11)
  30. 動態對比磁振造影影像評估聚焦式超音波局部開啟大鼠血腦障壁後之滲透量變化 (嚴慶齡醫學基金會CI-102-8)
  31. 聚焦式超音波暫態開啟血腦屏障後目標區域之相關蛋白質表現量及藥物動力學分析 (國科會NSC 101-2320-B-010-036-MY3)
  32. 超音波局部傳輸與標靶藥物對於腦腫瘤之協同治療作用(NRPB生技醫藥國家型科技計畫DOH101-TD-PB-111-TM012)
  33. 利用動態對比磁振造影影像評估聚焦式超音波局部開啟血腦障壁後之滲透量變化 (振陽研究計畫101F195CY18)
  34. F98神經膠質瘤在硼中子捕獲治療中以超音波局部開啟目標區域血腦屏障後18F-FBPA之藥物動力學評估 (2/2) (國科會NSC 100-2321-B-010-010)
  35. 聚焦式超音波增強標靶藥物於腦腫瘤滲透量之評估 (嚴慶齡醫學基金會CI-100-17)
  36. 單光子放射電腦斷層定量分析聚焦式超音波局部開啟血腦屏障 (振陽研究計畫100F117CY25)
  37. 超音波開啟目標區域血腦屏障以增強標靶藥物對腦腫瘤治療效率之評估 (榮台聯大VGHUST100-G1-3-3)
  38. F98神經膠質瘤在硼中子捕獲治療中以超音波局部開啟目標區域血腦屏障後18F-FBPA之藥物動力學評估 (1/2) (國科會NSC 99-2321-B-010-017)
  39. 磁振造影監控聚焦式超音波增強腦腫瘤藥物滲透量暨治療效果之研究  (國科會NSC 99-2314-B-010-028)
  40. 磁振造影定量分析聚焦式超音波增強腦腫瘤藥物滲透量 (嚴慶齡醫學基金會CI-99-8)
  41. 腦神經受體影像在注意力欠缺過動症轉譯研究-總計畫暨子計畫三 : 過動症受體造影效性及療效評估 (國科會99-NU-E-016-003-)
  42. 可估算血流收縮速度峰值之血壓計開發 (國科會NSC  98-2622-B-010-001-CC3)
  43. 磁振造影導引穿顱聚焦超音波促進藥物在目標區域通過血腦障壁之研究 (國科會NSC 97-2320-B-010-004)

學術著作：

Google Scholar

https://reurl.cc/65E0M6

Journal papers (*corresponding author)

  1. Tsung-Yu Pan, Yi-Ju Pan, Shih-Jen Tsai, Che-Wen Tsai, Feng-Yi Yang*, ” Focused ultrasound stimulates the prefrontal cortex and prevents MK-801-induced psychiatric symptoms of schizophrenia in rats”, Schizophrenia Bulletin, accepted, 2023 (SCI, IF:7.348; Rank:24/143 in “Psychiatry”)
  2. Wei-Shen Su, Chun-Hu Wu, Wen-Shin Song, Szu-Fu Chen, Feng-Yi Yang*, ” Low-intensity Pulsed Ultrasound Ameliorates Glia-mediated Inflammation and Neuronal Damage in Experimental Intracerebral Hemorrhage Conditions”, Journal of Translational Medicine, submitted, 2023 (SCI, IF:8.448; Rank:25/139 in “Medicine, Research & Experimental”)
  3. Feng-Yi Yang*, Wan-Hsuan Chan, Cong-Yong Gao, Yin-Ting Zheng, Chia-Hua Ke ” Transabdominal ultrasound alleviates LPS-induced neuroinflammation by modulation of TLR4/NF-κB signaling and tight junction protein expression”, Life Sciences, Vol. 325, 121769, 2023 (SCI, IF:6.780; Rank:36/279 in “Pharmacology & Pharmacy”)
  4. Chin-Hung Hsu, Yi-Ju Pan, Cong-Yong Gao, Raymond Y. Lo, Feng-Yi Yang* ” Ultrasound reduces inflammation by modulating M1/M2 polarization of microglia through STAT1/STAT6/PPARγ signaling pathways”, CNS Neuroscience & Therapeutics, revised, 2023 (SCI, IF:7.035; Rank:31/279 in “Pharmacology & Pharmacy”)
  5. Wen-Shin Song, Tai-Ho Hung, Shing-Hwa Liu, Yin-Ting Zheng, Hsin-Mei Lin, Feng-Yi Yang*, ”Neuroprotection by abdominal ultrasound in lipopolysaccharide-induced systemic inflammation”, International Journal of Molecular Sciences, Vol. 24, No. 11, pp.9329, 2023 (SCI, IF:6.208; Rank:69/296 in “Biochemistry & molecular biology”)
  6. Li-Hsin Huang, Zih-Yun Pan, Yi-Ju Pan, Feng-Yi Yang*, ” Magnetization transfer ratio for assessing remyelination after transcranial ultrasound stimulation in the lysolecithin rat model for multiple sclerosis”, Cerebral Cortex, Vol. 33, No. 4, pp.1403-1411, 2023 (SCI, IF:5.357; Rank:68/273 in “Neurosciences”)
  7. Feng-Yi Yang*, Yin-Ting Zheng, “Ultrasound Alleviates Lipopolysaccharide-Induced Colonic Damage”, Proceedings of the 2023 International Conference of the IEEE Engineering in Medicine and Biology Society, accepted, Sydney, Australia, Jul. 24-27, 2023 (EI).
  8. Feng-Yi Yang*, Li-Hsin Huang, Meng-Ting Wu, Zih-Yun Pan, ” Ultrasound neuromodulaiton reduces demyelination in a rat model of multiple sclerosis”, International Journal of Molecular Sciences, Vol. 23, No. 17, pp.10034, 2022 (SCI, IF:6.208; Rank:69/296 in “Biochemistry & molecular biology”)
  9. Che-Wen Tsai, Shih-Jen Tsai, Yi-Ju Pan, Hsin-Mei Lin, Tsung-Yu Pan, Feng-Yi Yang*, ” Transcranial ultrasound stimulation reverses behavior changes and the expression of calcium-binding protein in a rodent model of schizophrenia”, Neurotherapeutics, Vol. 19, No. 2, pp.649-659, 2022 (SCI, IF:7.620; Rank:17/276 in “Pharmacology & pharmacy”)
  10. Wen-Shin Song, Chen-Yu Sung, Chia-Hua Ke, Feng-Yi Yang*, ”Anti-inflammatory and neuroprotective effects of transcranial ultrasound stimulation on Parkinson’s disease”, Ultrasound in Medicine and Biology, Vol. 48, No. 2, pp.265-274, 2022 (SCI, IF: 2.998; Rank:7/31 in “Acoustics”)
  11. Pai-Kai Chiang, Wei-Kung Tsai, Wen-Hsiang Allen Chiu, Jhen-Bin Lin,Feng-Yi Yang*, Jie Lee”Muscle loss during androgen deprivation therapy is associated with higher risk of non-cancer mortality in high-risk prostate cancer”, Frontiers in Oncology, published on line, 2021 (SCI, IF:6.244; Rank:62/242in “Oncology”)
  12. Chen-Yu Sung, Pai-Kai Chiang, Che-Wen Tsai, Feng-Yi Yang*, ”Low-intensity pulsed ultrasound enhances neurotrophic factors and alleviates neuroinflammation in a rat model of Parkinson’s disease”, Cerebral Cortex, Vol. 32, No. 1, pp.176-185, 2022 (SCI, IF:5.357; Rank:68/273in “Neurosciences”)
  13. Tai-Ho Hung, Yu-Cheng Liu, Chun-Hu Wu, Chien-Cheng Chen, Hsien Chao, Feng-Yi Yang*, Szu-Fu Chen, ”Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction”, Brain Pathology, Vol. 31, No. 6, e12968, 2021 (SCI, IF:6.508; Rank:8/77in “Pathology”)
  14. Jia-Wei Chang, Meng-Ting Wu, Wen-Shin Song, Feng-Yi Yang*, ” Ultrasound stimulation suppresses LPS-induced proinflammatory responses by regulating NF-kB and CREB activation in microglial cells”, Cerebral Cortex, Vol. 30, No. 8, pp.4597-4606, 2020 (SCI, IF:6.559; Rank:16/252 in “Neurosciences”)
  15. Tao-Tao Chen, Tsuo-Hung Lan, Feng-Yi Yang*, ” Low-intensity pulsed ultrasound attenuates LPS-induced neuroinflammation and memory impairment by modulation of TLR4/ NF-kB signaling and CREB/BDNF expression”, Cerebral Cortex, Vol. 29, No. 4, pp.1430-1438, 2019 (SCI, IF:6.559; Rank:16/252 in “Neurosciences”)
  16. Pai-Kai Chiang, Feng-Yi Yang*, ” A Potential Treatment of Low Intensity Pulsed Ultrasound on Cavernous Nerve Injury for Erectile Dysfunction”, Medical Hypotheses, Vol. 122, pp.19-21, 2019 (SCI, IF:1.12; Rank:25/259 in “Neurosciences”)
  17. Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Shing-Hwa, Liu, Feng-Yi Yang*, ” Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction”, Scientific Reports, Vol. 8: 5568, 2018 (SCI, IF:4.259; Rank:10/64 in “Multidisciplinary sciences”)
  18. Szu-Fu Chen, Wei-Shen Su, Chun-Hu Wu, Tsuo-Hung Lan, Feng-Yi Yang*, ” Transcranial Ultrasound Stimulation Improves Long-term Functional Outcomes and Protects Against Brain Damage in Traumatic Brain Injury”, Molecular Neurobiology, Vol. 55, No. 8, pp.7079-7089, 2018 (SCI, IF:6.190; Rank:25/259 in “Neurosciences”)
  19. Yi-Li Lin, Meng-Ting Wu, Feng-Yi Yang*, ” Pharmacokinetics of Doxorubicin in Glioblastoma Multiforme following Ultrasound-Induced Blood-Brain Barrier Disruption as Determined by Microdialysis”, Journal of Pharmaceutical and Biomedical Analysis, Vol. 149, pp.482-487, 2018 (SCI, IF:3.255; Rank:18/76 in “Chemistry”)
  20. Wei-Shen Su, Chun-Hu Wu, Szu-Fu Chen, Feng-Yi Yang*, ” Transcranial Ultrasound Stimulation Promotes Brain-derived Neurotrophic Factor and Reduces Apoptosis in a Mouse Model of Traumatic Brain Injury”, Brain Stimulation, Vol. 10, No. 6, pp.1032-1041, 2017 (SCI, IF:6.078; Rank:16/194 in “Clinical Neurology”)
  21. Wei-Shen Su, Chun-Hu Wu, Szu-Fu Chen, Feng-Yi Yang*, ” Low-intensity pulsed ultrasound improves behavioral and histological outcomes after experimental traumatic brain injury”, Scientific Reports, Vol. 7: 15524, 2017 (SCI, IF:4.259; Rank:10/64 in “Multidisciplinary sciences”)
  22. Shing-Hwa Liu, Yi-Long Lai, Bo-Lin Chen, Feng-Yi Yang*, ”Ultrasound enhances the expression of brain-derived neurotrophic factor in astrocyte through activation of TrkB-Akt and Calcium-CaMK signaling pathways”, Cerebral Cortex, Vol. 27, No. 6, pp.3152-3160, 2017 (SCI, IF:8.665; Rank:16/252 in “Neurosciences”)
  23. Sin-Luo Huang, Chi-Wei Chang, Yi-Hsuan Lee, Feng-Yi Yang*, ” Protective effect of low-intensity pulsed ultrasound on memory impairment and brain damage in rats with vascular dementia”, Radiology, Vol. 282, No. 1, pp.113-122, 2017 (SCI, IF:6.867; Rank:2/125 in “Radiology”)
  24. Feng-Yi Yang*, Sheng-Fang Huang, Irene Han-Juo Cheng, ”Behavioral Alterations Following Blood-Brain Barrier Disruption Stimulated by Focused Ultrasound”, Oncotarget, Vol. 7, No. 19, pp.27916-27925, 2016 (SCI, IF:6.359; Rank:20/211 in “Oncology”)
  25. Wei-Shen Su, Min-Lan Tsai, Sin-Luo Huang, Shing-Hwa Liu, Feng-Yi Yang*, ”Controllable Permeability of Blood-Brain Barrier and Reduced Brain Injury through Low-Intensity Pulsed Ultrasound Stimulation”, Oncotarget, Vol. 6, No. 39, pp.42290-42299, 2015 (SCI, IF:6.359; Rank:20/211 in “Oncology”)
  26. Feng-Yi Yang*, Wen-Yuan Chang, Wei-Ting Lin, Jeng-Jong Hwang, Yi-Chun Chien, Hsin-Ell Wang, Min-Lan Tsai, ”Focused Ultrasound Enhanced Molecular Imaging and Gene Therapy for Multifusion Reporter Gene in Glioma-Bearing Rat Model”, Oncotarget, Vol. 6, No. 34, pp.36260-36268, 2015 (SCI, IF:6.359; Rank:20/211 in “Oncology”)
  27. Wei-Ting Lin, Ran-Chou Chen, Wen-Wei Lu, Shing-Hwa Liu, Feng-Yi Yang*, ” Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer’s disease rat model”, Scientific Reports, Vol. 5: 9671, 2015 (SCI, IF:5.078; Rank:5/55 in “Multidisciplinary sciences”)
  28. Feng-Yi Yang*, Wen-Wei Lu, Wei-Ting Lin, Chi-Wei Chang, Sin-Luo Huang, ” Enhancement of Neurotrophic Factors in Astrocyte for Neuroprotective Effects in Brain Disorders Using Low-Intensity Pulsed Ultrasound Stimulation”, Brain Stimulation, Vol. 8, No. 3, pp.465-473, 2015 (SCI, IF:5.432; Rank:36/251 in “Neurosciences”)
  29. Feng-Yi Yang*, Wen-Yuan Chang, Jyh-Cheng Chen, Lin-Chien Lee, Yi-Shun Hung, ”Quantitative Assessment of Cerebral Glucose Metabolic Rates after Blood-Brain Barrier Disruption Induced by Focused Ultrasound Using FDG-MicroPET”, NeuroImage, Vol. 90, pp.93-98, 2014 (SCI, IF:6.252; Rank:3/120 in “Radiology”)
  30. Feng-Yi Yang*, Wen-Yuan Chang, Jia-Je Li, Hsin-Ell Wang, Jyh-Cheng Chen, Chi-Wei Chang, ”Pharmacokinetic Analysis and Uptake of 18F-FBPA-Fr Following Ultrasound Induced Blood-Brain Barrier Disruption for Potential Use to Enhance Boron Delivery for Neutron Capture Therapy”, Journal of Nuclear Medicine, Vol. 55, No. 4, pp.616-621, 2014 (SCI, IF:5.774; Rank:6/120 in “Radiology”)
  31. Ying-Ling Chen**, Chung-Yih Wang**, Feng-Yi Yang**, Bo-Sheng Wang**, Jason Y. Chen, Liang-Ting Lin, Jyh-Der Leu, Fu-Du Chen, Yi-Jang Lee, Wei Chen, ”Synergistic effects of glycated chitosan with high-intensity focused ultrasound on suppression of metastases in a syngeneic breast tumor model”, Cell Death and Disease, Vol. 5, e1178, 2014 (**Equal first author; SCI, IF:6.044; Rank:35/185 in “Cell Biology”)
  32. Sheng-Yao Huang, Chia-En Ko, Gin-Shin Chen, I-Fang Chung, Feng-Yi Yang*, ” Focused Ultrasound Simultaneous Irradiation/MRI Imaging, and Two-stage General Kinetic Model”, PLOS ONE, Vol. 9, Issue 6, e100280, 2014 (SCI, IF:3.730; Rank:7/56 in “Multidisciplinary sciences”)
  33. Feng-Yi Yang*, Yi-Li Lin, Fong-In Chou, Yu-Chuan Lin, Yen-Wan Hsueh Liu, Lun-Wei Chang, Yu-Ling Hsieh, ” Pharmacokinetics of BPA in Gliomas with Ultrasound Induced Blood-Brain Barrier Disruption as Measured by Microdialysis”, PLOS ONE, Vol. 9, Issue 6, e100104, 2014 (SCI, IF:3.730; Rank:7/56 in “Multidisciplinary sciences”)
  34. Feng-Yi Yang*, Chia-En Ko, Sheng-Yao Huang, I-Fang Chung, Gin-Shin Chen, ” Pharmacokinetic Changes Induced by Focused Ultrasound in Glioma-Bearing Rats as Measured by Dynamic Contrast-Enhanced MRI”, PLOS ONE, Vol. 9, Issue 3, e92910, 2014 (SCI, IF:3.730; Rank:7/56 in “Multidisciplinary sciences”)
  35. Chun-Yi Wu, Pei-Chia Chan, Lin-Shan Chou, Chi-Wei Chang, Feng-Yi Yang, Ren-Shyan Liu, Shih-Hwa Chiou, Yi-Wei Chen, Sang-Hue Yen, Hsin-Ell Wang, ” Pulsed focused ultrasound enhances boron drug accumulation in a human head and neck cancer xenograft-bearing mouse model”, Molecular Imaging & Biology, Vol.16, Issue 1, pp.95-101, 2014 (SCI, IF:3.095; Rank:25/120 in “Radiology”)
  36. Feng-Yi Yang*, Wei-Hsiu Chiu, ”Focused Ultrasound-Modulated Glomerular Ultrafiltration Assessed by Functional Changes in Renal Arteries”, PLOS ONE, Vol. 8, Issue 1, e54034, 2013 (SCI, IF:4.092; Rank:12/84 in “Multidisciplinary sciences”)
  37. Feng-Yi Yang*, Chien-Cheng Chen, Yi-Hsuan Kao, Chuan-Lin Chen, Chia-En Ko, Shih-Cheng Horng, Ran-Chou Chen, ”Evaluation of Dose Distribution of Molecular Delivery after Blood-Brain Barrier Disruption by Focused Ultrasound with Treatment Planning”, Ultrasound in Medicine and Biology, Vol. 39, No. 4, pp. 620-627, 2013 (SCI, IF: 2.493; Rank:4/29 in “Acoustics”)
  38. Tse-Ying Liu, Meng-Yu Wu, Meng-Hsuan Lin, Feng-Yi Yang, ”A novel ultrasound-triggered drug vehicle with multimodal imaging functionality”, Acta Biomaterialia, Vol. 9, Issue 3, pp.5453-5463, 2013 (SCI, IF: 4.865; Rank:3/72 in “Engineering, Biomedical”)
  39. Feng-Yi Yang*, Hsin-Ell Wang, Ren-Shyan Liu, Ming-Che Teng, Jia-Je Li, Maggie Lu, Ming-Cheng Wei, Tai-Tong Wong, ”Pharmacokinetic Analysis of 111In-Labeled Liposomal Doxorubicin in Murine Glioblastoma with Blood-Brain Barrier Disruption Induced by Focused Ultrasound”, PLOS ONE, Vol. 7, Issue 9, e45468, 2012 (SCI, IF:4.092; Rank:12/84 in “Multidisciplinary sciences”)
  40. Feng-Yi Yang*, Yi-Wei Chen, Fong-In Chou, Sang-Hue Yen, Yi-Li Lin, Tai-Tong Wong, ”Boron Neutron Capture Therapy for Glioblastoma Multiforme: Enhanced Drug Delivery and Antitumor Effect Following Blood-Brain Barrier Disruption Induced by Focused Ultrasound”, Future Oncology, Vol. 8, Issue 10, pp.1361-1369, 2012 (SCI, IF:3.163; Rank:74/194 in “Oncology”)
  41. Feng-Yi Yang*, Tai-Tong Wong, Ming-Che Teng, Ren-Shyan Liu, Maggie Lu, Hsiang-Fa Liang, Ming-Cheng Wei, ”Focused Ultrasound and Interleukin-4 Receptor-Targeted Liposomal Doxorubicin for Enhanced Targeted Drug Delivery and Antitumor Effect in Glioblastoma Multiforme”, Journal of Controlled Release, Vol. 160, Issue 3, pp.652-658, 2012 (SCI, IF:7.164; Rank:10/249 in “Pharmacology & Pharmacy”)
  42. Feng-Yi Yang*, Pei-Yi Lee, ”Efficiency of Drug Delivery Enhanced by Acoustic Pressure During Blood-Brain Barrier Disruption Induced by Focused Ultrasound”, International Journal of Nanomedicine, Vol. 7, pp.2573-2583, 2012 (SCI, IF:4.976; Rank:18/249 in “Pharmacology & Pharmacy”)
  43. Feng-Yi Yang*, Ming-Che Teng, Maggie Lu, Hsiang-Fa Liang, Yan-Ru Lee, Chueh-Chuan Yen, Muh-Lii Liang, Tai-Tong Wong, ”Treating Glioblastoma Multiforme with Selective High-Dose Targeted Liposomal Doxorubicin Chemotherapy Induced by Repeated Focused Ultrasound”, International Journal of Nanomedicine, Vol. 7, pp.965-974, 2012 (SCI, IF:4.976; Rank:18/249 in “Pharmacology & Pharmacy”)
  44. Feng-Yi Yang*, Hsin-Ell Wang, Guan-Liang Lin, Hui-Hsien Lin, Tai-Tong Wong, ”Evaluation of the Increase in Permeability of the Blood-Brain Barrier during Tumor Progression after Pulsed Focused Ultrasound”, International Journal of Nanomedicine, Vol. 7, pp.723-730, 2012 (SCI, IF:4.976; Rank:18/249 in “Pharmacology & Pharmacy”)
  45. Feng-Yi Yang*, Guan-Liang Lin, Shih-Cheng Horng, Ran-Chou Chen, “Prenatal Exposure to Diagnostic Ultrasound Impacts Blood-Brain Barrier Permeability in Rats” Ultrasound in Medicine and Biology, Vol. 38, No. 6, pp.1051-1057, 2012 (SCI, IF: 2.493; Rank:4/29 in “Acoustics”)
  46. Shih-Cheng Horng, Feng-Yi Yang, Shieh-Shing Lin, “Apply PSO and OCBA to Minimize the Overkills and Re-probes in Wafer Probe Testing”, IEEE Transactions on Semiconductor Manufacturing, Vol. 25, No. 3, pp. 531-540, 2012 (SCI, IF:0.722; Rank:159/244 in “Engineering, Manufacturing”)
  47. Shih-Cheng Horng, Feng-Yi Yang, “Simulation-Based Meta-heuristic Approach for Booking Limits Problem at a Hotel Baby”, Proceedings of the 2012 International Conference on Information Security and Intelligent Control, pp. 153-156, 2012 (EI)
  48. Shih-Cheng Horng, Feng-Yi Yang, “Ordinal Optimization Based Algorithm for Hotel Booking Limits Problem”, Proceedings of the International Symposium on Computer, Consumer and Control 2012, pp. 759-762, 2012 (EI)
  49. Shih-Cheng Horng, Feng-Yi Yang*, Shieh-Shing Lin, ” Embedding Evolutionary Strategy in Ordinal Optimization for Hard Optimization Problems,” Applied Mathematical Modelling, Vol. 36, pp.3753-3763, 2012 (SCI, IF:1.371; Rank:16/87 in “Engineering, Multidisciplinary”)
  50. Shih-Cheng Horng, Shieh-Shing Lin, Feng-Yi Yang*, ” Evolutionary Algorithm for Stochastic Job Shop Scheduling with Random Processing Time,” Expert Systems With Applications, Vol. 39, pp.3603-3610, 2012 (SCI, IF:1.924; Rank:48/247 in “Engineering, Electrical & Electronic”)
  51. Shih-Cheng Horng, Feng-Yi Yang, “Optimal Base‐stock Policy of the Assemble to Order Systems”, Proceedings of the 17th International Symposium on Artificial Life and Robotics, pp. 816-819, 2012 (EI)
  52. Feng-Yi Yang*, Chien-Cheng Chen, Shih-Cheng Horng, Wei-Hsiu Chiu, Chi-Fang Yeh, ”Microbubble-enhanced functional changes in arteries induced by pulsed high-intensity focused ultrasound exposure,” Medical Engineering & Physics, 34(3), pp.313-317, 2012 (SCI, IF:1.906; Rank:28/69 in “Engineering, Biomedical”)
  53. Feng-Yi Yang*, Shih-Cheng Horng, “Ultrasound Enhanced Delivery of Macromolecular Agents in Brain Tumor Rat Model”, Conference Proceedings IEEE Engineering in Medicine and Biology Society, pp. 5573-5576, 2011 (EI)
  54. Feng-Yi Yang*, Hsin-Ell Wang, Guan-Liang Lin, Ming-Che Teng, Hui-Hsien Lin, Tai-Tong Wong, Ren-Shyan Liu, ”Micro-SPECT/CT-Based Pharmacokinetic Analysis of 99mTc-DTPA in Rats with Blood-Brain Barrier Disruption Induced by Focused Ultrasound,” Journal of Nuclear Medicine, Vol. 52, No. 3, pp.478-484, 2011 (SCI, IF:7.022; Rank:1/111 in “Radiology”)
  55. Feng-Yi Yang, Guan-Liang Lin, Shih-Cheng Horng, Tien-Kuei Chang, Shih-Yen Wu, Tai-Tong Wong, Hsin-Ell Wang, ” Pulsed High-Intensity Focused Ultrasound Enhances the Relative Permeability of the Blood-Tumor Barrier in a Glioma-Bearing Rat Model,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 58, No. 5, pp.964-970, 2011 (SCI, IF:1.460; Rank:9/29 in “Acoustics”)
  56. Wei-Hsiu Chiu, Tao-Hsin Tung, Pei-Hsuan Yu, Kuang-Shing Shey, Shih-Cheng Horng, Feng-Yi Yang*, “Normative curves of fetal limb bones length for the ethnic Chinese population,” Ultrasound in Obstetrics and Gynecology, accepted,  2011 (SCI, IF: 3.163; Rank:3/29 in “Acoustics”)
  57. Feng-Yi Yang*, Yu-Shi Lin, Kai-Hsiang Kang and Tai-Kuang Chao, ”Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation,” Journal of Controlled Release, 150(1) 111-116, 2011 (SCI, IF:7.164; Rank:10/249 in “Pharmacology & Pharmacy”)
  58. Shih-Cheng Horng, Feng-Yi Yang and Shieh-Shing Lin, ”Hierarchical Fuzzy Clustering Decision Tree for Classifying Recipes of Ion Implanter,” Expert Systems With Applications, Vol. 38, No. 1, pp.933-940, 2011 (SCI, IF:1.924; Rank:48/247 in “Engineering, Electrical & Electronic”)
  59. Shih-Cheng Horng, Feng-Yi Yang, “Combining Particle Swarm with Ordinal Optimization for Stochastic Simulation Optimization Problems”, Proceedings of the 8th Asian Control Conference, pp. 982-987, Kaohsiung, Taiwan, May 15-18 2011 (EI)
  60. Shih-Cheng Horng, Feng-Yi Yang, “Apply Particle Swarm Optimization to Maximize the Service Reliability of Grid Computing System”, Proceedings of the 25th International Conference on Information Networking,  pp. 235-240,  Kuala Lumpur, Malaysia, Jan. 26-28 2011 (EI)
  61. Feng-Yi Yang*, Shih-Cheng Horng, Yu-Shi Lin and Yi-Hsuan Kao, ”Association between contrast-enhanced MR images and blood-brain barrier disruption following transcranial focused ultrasound”, Journal of Magnetic Resonance Imaging, 2010; 32(3) 593-599 (SCI, IF:2.747; Rank:37/111 in “Radiology”)
  62. Wei-Hsiu Chiu, Tao-Hsin Tung, Ya-Shan Chen, Wei-Hsiung Wang, Shy-Mung Lee, Shih-Cheng Horng, Feng-Yi Yang*, “Normative curves of fetal nasal bone length for the ethnic Chinese population”, Irish Journal of Medical Science, Vol. 180, Number 1, pp.73-77, 2011 (SCI, IF: 0.661; Rank:95/151 in “Medicine”)
  63. Feng-Yi Yang*, Shih-Cheng Horng and Wei-Hsiu Chiu, ”Real-time ultrasound image-monitored focal changes of the vascular function in rats by pulsed HIFU”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 57, No. 7, pp.1594-1599, 2010 (SCI, IF:1.460; Rank:9/29 in “Acoustics”)
  64. Jun-Cheng Weng, Sheng-Kai Wu, Feng-Yi Yang, Win-Li Lin and Wen-Yih Tseng, “Pulse Sequence and timing of contrast-enhanced MRI for assessing blood-brain barrier disruption after transcranial focused ultrasound in the presence of hemorrhage”, Journal of Magnetic Resonance Imaging, 2010; 31(6) 1323-1330 (SCI, IF:2.747; Rank:37/111 in “Radiology”)
  65. Feng-Yi Yang*, Wei-Hsiu Chiu, Chi-Fang Yeh, “Color doppler sonographic evaluation of peak systolic velocity and pulsatility index in artery after pulsed HIFU exposure”, American Institute of Physics (AIP) conference proceedings,  2010 (EI)
  66. Feng-Yi Yang*, Wei-Hsiu Chiu, Shing-Hwa Liu and Feng-Ming Ho, “The length ratios between fetal limb bones and nasal bone in the general population”, European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 148, No. 1, pp.99-100, 2010 (SCI, IF: 1.764; Rank:35/75 in “Obstetrics & Gynecology”)
  67. Feng-Yi Yang*, Wei-Hsiu Chiu, Shing-Hwa Liu, Guan-Liang Lin, and Feng-Ming Ho, ”Functional Changes in Arteries Induced by Pulsed High-Intensity Focused Ultrasound”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 56, No. 12, pp.2643-2649, 2009 (SCI, IF:1.460; Rank:9/29 in “Acoustics”)
  68. Feng-Yi Yang*, Shing-Hwa Liu, Feng-Ming Ho, Chi-Hong Chang, “Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption”, The Journal of the Acoustical Society of America, Vol. 126, No. 6, pp.3344-3349, 2009 (SCI, IF: 1.644; Rank:6/29 in “Acoustics”)
  69. Feng-Yi Yang, Wen-Mei Fu, Wen-Shiang Chen, Wei-Lan Yeh and Win-Li Lin, “Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain barrier disruption”, Ultrasonics Sonochemistry, Vol. 15, No. 4, pp.636-643, 2008 (SCI, IF: 3.199; Rank:2/29 in “Acoustics”)
  70. Feng-Yi Yang, Wen-Mei Fu, Rong-Sen Yang, Houng-Chi Liou, Kai-Hsiang Kang and Win-Li Lin, “Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption”, Ultrasound in Medicine and Biology, Vol. 33, No. 9, pp.1421-1427, 2007 (SCI, IF: 2.493; Rank:4/29 in “Acoustics”)
  71. Feng-Yi Yang, Tzu-Jung Mao, Yung-Yaw Chen, Hsu Chang, Win-Li Lin, “Beam steering and focusing ability of a contact ultrasound transducer for transskull brain disease therapy”, Biomedical Engineering – Applications, Basis, and Communications, Vol. 18, No. 6, pp.328-336, 2006 (SCI)
  72. F.Y. Yang, W.M. Fu, H.C. Liou, W.S. Chen, W.L. Lin, “In-vivo Investigation of the Effects of Ultrasound Contrast Agent and Focused Ultrasound on Blood-Brain Barrier Disruption”, IEEE Ultrasonics Symposium, pp.1592-1595, 2006 (EI)
  73. S.C. Horng, S.Y. Lin, M.H. Cheng, F.Y. Yang, C.H. Liu, W.Y. Lee, C.H. Tsai, “Reducing the Overkills and Retests in Wafer Testing Process”, IEEEI/SEMI Advanced Semiconductor Manufacturing Conference and Workshop, pp.286-291, 2003 (EI)

Conference papers (*corresponding author)

  1. Feng-Yi Yang*, Yin-Ting Zheng, “Ultrasound Alleviates Lipopolysaccharide-Induced Colonic Damage”, Proceedings of the 2023 International Conference of the IEEE Engineering in Medicine and Biology Society, accepted, Sydney, Australia, Jul. 24-27, 2023 (EI).
  2. Feng-Yi Yang*, Jia-Wei Chang, Cong-Yong Gao, “Ultrasound Alleviates LPS-induced Inflammation in Microglia”, 8th International Conference on Advanced Technology Innovation, Okinawa, Japan, April 01-05, 2023.
  3. Wei-Shen Su, Chun-Hu Wu, Feng-Yi Yang*, “Investigation of the transcranial ultrasound stimulation on neuron deficits in intracerebral hemorrhage animal model”, 5th Global Conference on Biomedical Engineering, Taipei, Taiwan, December 15-17, 2022.
  4. Zih-Yun Pan, Li-Hsin Huang, Feng-Yi Yang*, “Low-intensity pulsed ultrasound stimulation enhances remyelination in lysolecithin-induced model of multiple sclerosis”, 5th Global Conference on Biomedical Engineering, Taipei, Taiwan, December 15-17, 2022. (Best student award)
  5. Nai-Jie Hsiaw, Chun-Yen Lee, Szu-Fu Chen, Feng-Yi Yang*, “Low-intensity pulsed ultrasound improved cognitive function after experimental traumatic brain injury: Reducing the activation of astrocyte and microglia”, 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology, Taipei, Taiwan, November 7-11, 2022.
  6. Zih-Yun Pan, Li-Hsin Huang, Feng-Yi Yang*, “Monitoring remyelination by MRI after transcranial ultrasound stimulation in the rat brain”, 4thAsian Society of Magnetic Resonance in Medicine, Taipei, Taiwan, May 21-22, 2022.
  7. Feng-Yi Yang*, Tao-Tao Chen, “Ultrasound Protects against Ab-Mediated Cell Death”, International Conference on Advanced Technology Innovation, Sapporo, Hokkaido, Japan, July 15-18, 2019.
  8. Feng-Yi Yang*, Tao-Tao Chen, “Transcranial Ultrasound Improves Behavioral Performance via Anti-Neuroinflammation”, Proceedings of the 2018 International Conference of the IEEE Engineering in Medicine and Biology Society, pp.5573-5576, Hawaii, USA, Jul. 17-21, 2018 (EI).
  9. Wei-Shen Su, Chun-Hu Wu, Szu-Fu Chen, Feng-Yi Yang*, “Effect of Ultrasound Treatment in Traumatic Brain Injury Mice”, Neuroscience 2017, Washington, DC, USA, November 11-15, 2017.
  10. Wei-Shen Su, Feng-Yi Yang*, “Ultrasound Attenuates Blood-Brain Barrier Disruption and Cerebral Edema after Traumatic Brain Injury in Mice”,  International Journal of Psychiatry and Psychotherapy, 2, 54-57; 5th International Conference on Neurology, Agia Pelagia Beach, Heraklion, Crete, Greece, July 14-17, 2017.
  11. Wei-Shen Su, Feng-Yi Yang*, “Protective Effect of Ultrasound on Brain Injury in Mice”, International Society for Therapeutic Ultrasound (ISTU), Nanjing, China, May 31-June 2, 2017.
  12. Wei-Shen Su, Feng-Yi Yang*, “Controllable Permeability of Blood-Brain Barrier and Reduced Brain Injury through Low-Intensity Pulsed Ultrasound Stimulation”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2016.
  13. Feng-Yi Yang*, Sheng-Fang Huang, “Behavioural Assessment of Blood-Brain Barrier Opening Induced by Various Ultrasound Parameters”, International Conference on Advanced Technology Innovation, Bali, Indonesia, June 30-July 3, 2016.
  14. Feng-Yi Yang*, Sin-Luo Huang, “Protective Effect of Ultrasound on Brain Damage in Rats with Chronic Cerebral Hypoperfusion”, International Society for Therapeutic Ultrasound (ISTU), Tel Aviv, Israel, March 14-16, 2016.
  15. Yi-Li Lin, Chia-En Ko, Sheng-Yao Huang, I-Fang Chung, Feng-Yi Yang*,  “Duration and leakage of focused-ultrasound induced blood-brain barrier opening in rats measuring by dynamic contrast-enhanced MRI”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2015.
  16. Feng-Yi Yang*, Wen-Yuan Chang, Wei-Ting Lin, Jeng-Jong Hwang,  “Enhancement of gene delivery using focused ultrasound on brain tumor”, 2015 Annual Main Meeting of the Society of Experimental Biology,  Prague, Czech Republic, June 29-July 3, 2015.
  17. Feng-Yi Yang*, “Ultrasound Target Drug Delivery”, 7th Asian Oncology Summit, Shanghai, China, Apr. 10-12, 2015.
  18. Sin-Luo Huang, Chia-En Ko, Feng-Yi Yang*, “Pharmacokinetic Changes Induced by Focused Ultrasound in Brain Tumor as Assessed by Dynamic Contrast-Enhanced MRI”, 9th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2014.
  19. Shih-Cheng Horng, Feng-Yi Yang, “Optimization of broadband wireless networks with centralized control using memetic algorithm”, Proceedings of the 28th International Conference on Information Networking,  Phuket, Thailand, Feb. 10-12, 2014.
  20. Yi-Li Lin, Wen-Yuan Chang, Hsin-Ell Wang, Jyh-Cheng Chen, Feng-Yi Yang*, “Pharmacokinetics of 18F-FBPA-Fr with Focused Ultrasound-Induced BBB-Disruption from micro-PET Imaging”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2013.
  21. Sheng-Yao Huang, Yi-Cheng Chen, Feng-Yi Yang, I-Fang Chung, Chun-Hung Su, “Finding Marker Genes from High Dimensional Expression Profiles: Divide-and-conquer Exploiting a Fuzzy Rule Based Framework”, Proceedings of the 2013 International Conference on Fuzzy Systems, pp.1-6, Hyderabad, India, Jul. 7-10, 2013 (EI)
  22. Feng-Yi Yang*, Shih-Cheng Horng, “Chemotherapy of Glioblastoma by Targeted Liposomal Platinum Compounds with Focused Ultrasound”, Proceedings of the 2013 International Conference of the IEEE Engineering in Medicine and Biology Society, pp.5573-5576, Osaka, Japan, Jul. 3-7, 2013 (EI)
  23. Shih-Cheng Horng, Feng-Yi Yang, “Optimal Base-Stock Level of the Stochastic Economic Lot Scheduling Problem”, Proceedings of the 2013 International Conference on Computing, Management and Telecommunications, pp. 380-385, Ho Chi Minh, Vietnam, Jan. 21-24, 2013.
  24. Feng-Yi Yang*, Shih-Cheng Horng, “Ultrasound Mediated Delivery of Liposomal Doxorubicin in Mice with Glioma”, Proceedings of the 2012 International Conference on Biomedical Engineering and Biotechnology, pp.68-71, Beijing, China, OCT. 26-28, 2012.
  25. Feng-Yi Yang*, Yi-Li Lin, “Investigation of Bone Ratios for Prenatal Fetal Assessment in Taiwanese Population”, Proceedings of the 2012 International Conference on Biomedical Engineering and Biotechnology, pp.146-149, Beijing, China, OCT. 26-28, 2012.
  26. Chia-En Ko, Feng-Yi Yang*, “The Change of Permeability of Blood-Brain Barrier Opening Induced with Foucsed Ultrasound as Measured by Dynamic Gd-DTPA-Enhanced MRI”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  27. Wen-Yuan Chang, Feng-Yi Yang*, Jhih-Shian Lee, Jyh-Cheng Chen, “Image-Derived Input Functions for Small-Animal 4-Borno-2-18F-Fluoro-L-Phenylalanine PET Studies”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  28. Yi-Li Lin, Feng-Yi Yang*, “Enhanced Antitumor Effect for Boron Neuron Capture Therapy with Local Blood-Brain Barrier Disruption Induced by Focused Ultrasound”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  29. Wen-Wei Lu, Ming-Che Teng, Feng-Yi Yang*, “Combining Focused Ultrasound and Targeted Liposomal Doxorubicin for Enhanced Treatment in Glioblastoma Multiforme”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  30. Wei-Ting Lin, Ming-Che Teng, Feng-Yi Yang*, “Pharmacokinetic Evaluation of 111In-Labeled Targeted Drug in Brain Tumor after Blood-Brain Barrier Opening with Focused Ultrasound”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  31. Jium-Yu Liu, Chia-En Ko, Feng-Yi Yang*, “Dose Distribution of Drug Delivery with Blood-Brain Barrier Disruption by Focused Ultrasound”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  32. Wei-Shen Su, Ming-Che Teng, Feng-Yi Yang*, “Repeated Focused Ultrasound Enhanced Targeted Chemotherapy for Glioblastoma Multiforme”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2012.
  33. Chia-En Ko, Feng-Yi Yang*, “Analysis of the Permeability of Blood-Brain Barrier Opening Induced by Foucsed Ultrasound Using Dynamic Contrast-Enhanced MRI”, 7th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2012.
  34. Wen-Yuan Chang, Feng-Yi Yang, Jhih-Shian Lee, Jia-Je Li, Yu-ling Hsieh, Hsu-Yin Tseng, Zhi-Wei Chang, Hsin-Ell Wang, Jyh-Cheng Chen, “Evaluation of Pharmacokinetics of 4-Borno-2-18F -Fluoro-L-Phenylalanine for Boron Neutron Capture Therapy in a Glioma-Bearing Rat Model with Ultrasound Induced targeted Blood-Brain Barrier Disruption”, 7th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2012.
  35. Shih-Cheng Horng, Feng-Yi Yang, “Simulation-Based Meta-heuristic Approach for Booking Limits Problem at a Hotel Baby”, Proceedings of the 2012 International Conference on Information Security and Intelligent Control, pp. 153-156, Yunlin, Taiwan, Aug. 14-16, 2012 (EI)
  36. Shih-Cheng Horng, Feng-Yi Yang, “Ordinal Optimization Based Algorithm for Hotel Booking Limits Problem”, Proceedings of the International Symposium on Computer, Consumer and Control 2012, pp. 759-762, Taichung, Taiwan, June 4-6 2012 (EI)
  37. Shih-Cheng Horng, Feng-Yi Yang, “Optimal Base‐stock Policy of the Assemble to Order Systems”, Proceedings of the 17th International Symposium on Artificial Life and Robotics, pp. 816-819, Oita, Japan, Jan. 19-21 2012 (EI)
  38. Feng-Yi Yang*,Shih-Cheng Horng, “Ultrasound Enhanced Delivery of Macromolecular Agents in Brain Tumor Rat Model”, 33rd Annual International Conference IEEE Engineering in Medicine and Biology Society, pp. 5573-5576, Boston, USA, Aug. 30th- Sep. 3rd , 2011 (EI)
  39. Shih-Cheng Horng, Feng-Yi Yang, “Combining Particle Swarm with Ordinal Optimization for Stochastic Simulation Optimization Problems”, Proceedings of the 8th Asian Control Conference, pp. 982-987, Kaohsiung, Taiwan, May 15-18 2011 (EI)
  40. Shih-Cheng Horng, Feng-Yi Yang, “Apply Particle Swarm Optimization to Maximize the Service Reliability of Grid Computing System”, Proceedings of the 25th International Conference on Information Networking,  pp. 235-240,  Kuala Lumpur, Malaysia, Jan. 26-28 2011 (EI)
  41. Ming-Che Teng, Tai-Tong Wong, Feng-Yi Yang*, “Impact of focused ultrasound-enhanced doxorubicin delivery on tumor volume in mice with glioma”, 6th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2011.
  42. Ming-Che Teng, Guan-Liang Lin, Feng-Yi Yang*, “Non-Invasive Quantitative the Blood-Brain Barrier Permeability by Local Enhancement of Focused Ultrasound”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2010.
  43. Feng-Yi Yang*, Wei-Hsiu Chiu, Chi-Fang Yeh, “Color doppler sonographic evaluation of peak systolic velocity and pulsatility index in artery after pulsed HIFU exposure”, International Symposiumon therapeutic ultrasound,  Tokyo Japan, 2010 (EI)
  44. Guan-Liang Lin, Ming-Che Teng, Hui-Hsien Lin, Hsin-Ell Wang, Feng-Yi Yang*, “Investigation of the effect of pulsed-HIFU on the permeability of blood-tumor barrier in rats”, 5th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2010.
  45. Yu-Shi Lin, Chia-En Ko, Yi-Hsuan Kao, Feng-Yi Yang*, “The effect of repeated focused ultrasound on the permeability of blood-brain barrier”, 5th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2010.
  46. Sheng-Fang Huang, Yi-An Lin, Feng-Yi Yang*, “Behavioural evaluation for blood-brain barrier disruption induced by focused ultrasound”, 5th International Symposium of Medical Imaging and Radiological Sciences, ROC, 2010.
  47. Feng-Yi Yang*, Chi-Hong Chang, “Effect of microbubble dose on the reversibility of focused-ultrasound-induced blood-brain barrier disruption”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2009.
  48. Wei-Hsiu Chiu, Guan-Liang Lin, Feng-Yi Yang*, “Functional changes in arteries induced by high-intensity focused ultrasound”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2009.
  49. Wei-Hsiu Chiu, Shih-Cheng Horng, Feng-Yi Yang*, “The length ratios between fetal natal bone and limb bones in the general population”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2009.
  50. Yu-Shi Lin, Shih-Cheng Horng, Shuo-Hui Hung, Feng-Yi Yang*, “Effect of ultrasound parameters on the duration of focused-ultrasound-induced blood-brain barrier disruption”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2009.
  51. Guan-Liang Lin, Feng-Yi Yang*, “Pulsed-HIFU enhances permeability of the blood-tumor barrier in F-98 glioma of F-344 rats”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2009.
  52. J-C. Weng, S-K. Wu, F-Y. Yang, W-L. Lin and W-Y. I. Tseng, “Determination of Pulse Sequence and Timing of Contrast-enhanced MRI for Assessing Blood-brain Barrier Disruption Following Transcranial Focused Ultrasound”, ISMRM 17th Scientific Meeting and Exhibition in Honolulu, Hawaii, USA, 2009.
  53. Shih-Cheng Horng, Feng-Yi Yang*, “An expert system for the fault diagnosis of computer hardware”, International conference on advanced information technology, ROC, 2009.
  54.  W.H. Chiu, G.L. Lin, W.H. Wang, F. Y. Yang*, “The relation between fetal nasal bone length & head circumference in Taiwanese general population”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2008.
  55. W.H. Chiu, Y.S. Lin, S.H. Hung, F. Y. Yang*, “The relationship between fetal nasal bone length and head circumference in the prenatal ultrasound examination”, 4th Conference of International Medical Imaging and Radiological Sciences, 2008.
  56. F. Y. Yang, W.M. Fu, W.S. Chen, W.L. Lin, “The Focused Ultrasound with a Contrast Agent for Non-invasive Blood-Brain Barrier Disruption”, Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2007.
  57. F.Y. Yang, W.M. Fu, W.S. Chen, W.L. Lin, “Investigation of Focused Ultrasound with a Contrast Agent on Local Blood-Brain Barrier Disruption”, International Workshop on Modeling and Simulation in Health , ROC, 2007.
  58. F.Y. Yang, W.M. Fu, W.S. Chen, W.L. Lin, “Contrast-Agent-Enhanced the disruption of blood-brain-barrier by focused ultrasound through an intact skull”, International Symposiumon therapeutic ultrasound, Seoul, Korea,2007.
  59. F.Y. Yang, W.M. Fu, H.C. Liou, W.S. Chen, W.L. Lin, “In-vivo Investigation of the Effects of Ultrasound Contrast Agent and Focused Ultrasound on Blood-Brain Barrier Disruption”, IEEE Ultrasonics Symposium, 1592-1595, Vancouver, Canada, 2006 (EI)
  60. F.Y. Yang, H.L. Liu, Y.Y. Chen,  W.L. Lin, “Beam steering at low frequencies for noninvasive brain disease therapy with a hemispherical ultrasound transducer”, Ultrasound in Medicine & Biology, Vol. 32, No. 5S, pp. 278, Seoul, Korea, 2006.
  61. F.Y. Yang, W.M. Fu, H.C. Liou, W.S. Chen, W.L. Lin, “The Investigation of Contrast-Agent Enhanced Blood-Brain Barrier Disruption”, International Symposium on Biomedical Engineering,10018, ROC, 2006.
  62. F.Y. Yang, T.J. Mao, Y.Y. Chen, H. Chang, W.L. Lin, “Beam Steering and Focusing Ability of a Contact Ultrasound Transducer for Transskull Brain Disease Therapy”, International Symposium on Biomedical Engineering,10019, ROC, 2006.
  63. F. Y. Yang, W.M. Fu, H.C. Liou, W.S. Chen, W.L. Lin, “Quantitative evaluation of contrast agent enhanced local blood-brain barrier disruption by focus ultrasound,” Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2006.
  64. F. Y. Yang, H.L. Liou, Y.Y. Chen, W.L. Lin, “Beam Steering at Low Frequencies for Noninvasive Brain Disease Therapy with a Hemispherical Ultrasound Transducer,” Proceeding of the Annual Conference of the Biomedical Engineering Society, ROC, 2006.
  65. S.C. Horng, S.Y. Lin, M.H. Cheng, F.Y. Yang, C.H. Liu, W.Y. Lee, C.H. Tsai, “Reducing the Overkills and Retests in Wafer Testing Process”, IEEEI/SEMI Advanced Semiconductor Manufacturing Conference and Workshop, pp.286-291, 2003 (EI)
  66. H. H. Chang, F. Y. Yang, Y. J. Tseng, W. C. Chu, W. Y. Chung, D. H. C. Pan, “A PC-Based Dose Calculation System for Gamma Knife Stereotactic Radiosurgery,” Proceeding of the Annual Conference of the Biomedical Engineering Society, pp.24-25, ROC, 1997.

出版品:

楊逢羿「超音波原理與儀器 第八版」 (ELSEVIER TAIWAN LLC)

Patents

  1. Feng-Yi Yang, An Ultrasound Generator for Inhibiting Intestinal Inflammatory Factor and/or Improving Neuroinflammation and its System and Method Thereof. (US Patent No.: 18/194,743)
  2. 楊逢羿, 抑制腸道發炎因子及/或改善神經發炎之超音波產生裝置及系統. (ROC發明專利申請案號: 111147845)
  3. Feng-Yi Yang, Ultrasound stimulation helmet. (US Patent No.: US10940335 B2, 專利權起迄日: 2021/03/09–2036/11/23)
  4. 楊逢羿, 超音波刺激頭盔. (中國發明專利號: 201580083270.6, 專利權起迄日: 2020/09/28–2035/10/14)
  5. 楊逢羿, 超音波刺激頭盔. (日本發明專利證書號: 特許第6670485號, 專利權起迄日: 2020/03/04–2035/10/14)
  6. 楊逢羿, 用於治療及／或預防神經退化性疾病的低強度脈衝式超音波器具. (ROC發明專利證書號: I 615172, 專利權起迄日: 2018/02/21–2034/09/03)
  7. Feng-Yi Yang, I-Fang Chung, Sheng-Yao Huang, Blood-Brain Barrier Recovery Curve Assessment Method and System. (US Patent No.: US9291692 B2, Published date: 2016/03/22)
  8. 楊逢羿, 鍾翊方, 黃聖堯, 血腦障壁恢復曲線之評估方法及系統. (ROC證書號: I 489307, 專利權起迄日: 2015/06/21–2033/09/05)
  9. Feng-Yi Yang, Methods and system for ultrasound-mediated drug delivery. (US Patent No.: US9072879 B2, Date of Patent: 2015/07/07)
  10. Feng-Yi Yang, Wei-Hsiu Chiu, Synchronic monitor system for drug delivery induced by ultrasound and the method thereof. (US Patent No.: US2012/0010502 A1, Published date: 2012/01/12)
  11. 楊逢羿, 邱偉修, 同步監控超音波導引藥物傳輸機制的系統及其方法. ( ROC證書號: I 454247, 專利權起迄日: 2014/10/01–2030/07/08)
  12. Yang, Feng-Yi, Method and apparatus for dispensing fluid doses. (US Patent No.: US6595390, Published date: 2003/07/22)
  13. Yang, Feng-Yi, Microelectronic fabrication die electrical probe apparatus electrical test method providing enhanced microelectronic fabrication die electrical test accuracy and efficiency. (US Patent No.: US6440757, Published date: 2002/08/27)
  14. Yang, Feng-Yi, Method and apparatus for calibrating a dissolved oxygen analyzer. (US Patent No.: US6330819, Published date: 2001/12/18)
  15. Yang, Feng-Yi, Huang, Wei-tien, Apparatus and method for monitoring fluorine ions. (US Patent No.: US6306284, Published date: 2001/10/23)
  16. Yang, Feng-Yi, Apparatus for sensing liquid level. (US Patent No.: US6067854, Published date: 2000/05/30)
  17. 楊逢羿, 一種高效率之晶片探針測試方法. (ROC證書號: 206098, 專利權起迄日: 2004/06/21–2021/10/18
  18. 楊逢羿, 連續式氟離子監測裝置. ( ROC證書號: 218126, 專利權起迄日: 2004/01/11–2011/01/25)
  19. 楊逢羿, 具有自動校正功能的溶氧分析儀. ( ROC證書號: 173937, 專利權起迄日: 2001/05/16–2011/06/29)
  20. 楊逢羿, 廢水處理系統之加藥監測裝置. ( ROC證書號: 162325, 專利權起迄日: 2000/08/01–2010/11/05)
  21. 楊逢羿, 組合式液位控制開關. ( ROC證書號: 150487, 專利權起迄日: 1999/08/01–2010/11/09)

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