吳駿一 副教授

學歷
國立陽明大學 生物醫學影像暨放射科學研究所博士
研究專長
放射化學、核醫藥物、分子影像

實驗室網站

吳駿一老師 實驗室網站

Education

2009-2013       國立陽明大學 生物醫學影像暨放射科學系 博士

2005-2007       國立陽明大學 生物醫學影像暨放射科學系 碩士

2001-2005       國立陽明大學 醫學放射技術學系 學士

Major

Radiopharmaceutical Chemistry

Research interests

Radiopharmaceutical Chemistry (放射化學)

Molecular Imaging (分子影像)

Nuclear Medicine (核醫藥物)

Previous Position

2014 Aug. – 2020 Jan.   中國醫藥大學 生物醫學影像暨放射科學學系 助理教授

2013 Feb. – 2014 July    台灣新吉美碩股份有限公司 運轉員/研究員

Licenses

  1. 輻射防護師認可證書
  2. 醫事放射師證書
  3. 放射性物質生產設施運轉人員證書

Honors

  1. 中國醫藥大學104學年度校級傑出教授獎(助理教授組)
  2. 中國醫藥大學103學年度系級績優導師
  3. 斐陶斐協會榮譽會員 (2007)

Research Interests

核子醫學影像可非侵入性地提供功能性影像(functional imaging)，本實驗室主要研究目標即是利用核醫影像應用於癌症早期診斷與治療、腦神經科學研究、硼中子捕獲治療及探討各型新型藥物之藥物動力學。

Publications

Peer-reviewed Articles

  1. *Chun-Yi Wu, Jia-Jia Lin, Wen-Yi Chang, Cheng-Ying Hsieh, Chin-Ching Wu, Hong-Sen Chen, Hung-Ju Hsu, An-Suei Yang, Ming-Hua Hsu, *Wei-Ying Kuo. Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT). Colloids and Surfaces B: Biointerfaces 2019;183:110387
  2. Chun-Yi Wu, Yang-Yi Chen, Jia-Jia Lin, Jui-Ping Li, Jen-Kun Chen, *Te-Chun Hsieh, *Chia-Hung Kao. Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat model of Parkinson’s disease. BMC Medical Imaging 2019;19:78
  3. Shin-Lei Peng, Han Chiu, Chun-Yi Wu, Chiun-Wei Huang, Yi-Hsiu Chung, Cheng-Ting Shih, Wu-Chung Shen. The effect of caffeine on cerebral metabolism during alpha-chloralose anesthesia differs from isoflurane anesthesia in the rat brain. Psychopharmacology 2019;236(6):1749-1757
  4. Chin-Ho Tsao, Chun-Yi Wu, Chi-Wei Chang, Hsin-Ell Wang, Bing-Fu Shih, Ren-Shyan Liu. Micro-PET imaging of [18F]fluoroacetate combined with [18F]FDG to differentiate chronic Mycobacterium tuberculosis infection from an acute bacterial infection in a mouse model: a preliminary study. Nucl Med Commun. 2019;40(6):639-644
  5. Wei-Ying Kuo, Hung-Ju Hsu, Chun-Yi Wu, Hong-Sen Chen, Yu-Chi Chou, Yueh-Liang Tsou, Hung-Pin Peng, Jhih-Wei Jian, Chung-Ming Yu, Yi-Kai Chiu, Ing-Chien Chen, Chao-Ping Tung, Michael Hsiao, Chia-Lung Lin, Yong Alison Wang Andrew H-J. Wang, An-Suei Yang. Antibody-drug conjugates with HER2-targeting antibodies derived from synthetic antibody libraries are highly potent against HER2 positive human gastric tumor in xenograft models. MAbs. 2019;11(1):153-165
  6. Wei-Ying Kuo, Jia-Jia Lin, Hung-Ju Hsu, Hong-Sen Chen, An-Suei Yang, *Chun-Yi Wu. Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model. Sci Rep. 2018;8(1):13735-13744.
  7. Chun-Yi Wu, Jo-Hsin Tang, Pei-Chia Chan, Jia-Je Li, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang. Monitoring tumor response after liposomal Doxorobicin in combination with liposomal vinorelbine treatment using 3’-deoxy-3’[18F]fluorothymidine PET. Mol Imag Biol 2017 Jun;19(3):408-420.
  8. Wei-Ying Kuo, Luen Hwu, Chun-Yi Wu, Jhih-Shian Lee, Chi-Wei Chang, Ren-Shyan Liu. STAT3/NF-κB-regulated lentiviral TK/GCV suicide gene therapy for cisplatin-resistant triple-negative breast cancer. Theranositics 2017;7(3):647-663.
  9. Yo-Liang Lai, Chun-Yi Wu, K. S. Clifford Chao. Biological Imaging in clinical oncology: radiation therapy on functional imaging. Int J Clin Oncol. 2016;21(4):626-632.
  10. *Wei-Ying Kuo, *Chun-Yi Wu (co-first author), Luen Hwu, Jhih-Shian Lee, Cheng-Han Tsai, Kang-Ping Lin, Hsin-Ell Wang, The-Ying Chou, Chun-Ming Tsai, Juri Gelovani, Ren-Shyan Liu. Enhancement of tumor initiation and expression of KCNMA1, MORF4L2, and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment. Oncotarget 2015;6(11):8663-8675.
  11. *Pei-Chia Chan, *Chun-Yi Wu (co-first author), Lin-Shan Chou, Chung-Hsien Ho, Chi-Wei Chang, Shih-Hwa Chiou, Wuu-Jyh Lin, Fu-Du Chen, C. Allen Chang, Jeng-Jong Hwang, Ren-Shyan Liu, Hsin-Ell Wang. Monitoring tumor response after histone deacetylase inhibitor treatment using 3’-deoxy-3’[18F]-fluorothymidine PET. Mol Imag Biol 2015;17:394-402.
  12. *Chun-Yi Wu, *Pei-Chia Chan, Lin-Shan Chou, Chi-Wei Chang, Feng-Yi Yang, Ren-Shyan Liu, Shih-Hwa Chiou, Sang-Hue Yen, Yi-Wei Chen, Hsin-Ell Wang. Pulsed focused ultrasound enhances boron drug accumulation in a human head and neck cancer xenograft-bearing mouse model. Mol Imag Biol 2014;16:95-101
  13. *Pei-Chia Chan, *Chun-Yi Wu (co-first author), Wei-Ting Chang, Chih-Yuan Lin, Ren-Shyan Liu, Mian M Alauddin, Wuu-Jyh Lin, Hsin-Ell Wang. Monitoring tumor response with 18F-FMAU in a sarcoma-bearing mouse model after liposomal vinorelbine treatment. Nucl Med & Biol. 2013;40:1035-1042.
  14. Wen-Yi Chang, Wei-Ti Kuo, Chun-Yi Wu, Chih-Yuan Lin, Pei-Chia Chan, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang, Chuan-Lin Chen. Evaluation of 131/125I-5-2’-deoxycytidine as a novel proliferation probe in a tumor mouse model. Appl Radiat Isot. 2013;77:166-173.  
  15. Chun-Yi Wu, Lin-Shan Chou, Pei-Chia Chan, Chung-Hsien Ho, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Wuu-Jyh Lin, Hsin-Ell Wang. Monitoring tumor response with radiolabeled nucleoside analogues in a hepatoma-bearing mouse model early after Doxisome® treatment. Mol Imag Biol 2013;15:326-335
  16. Chun-Yi Wu, Hsin-Ell Wang, Ming-Hsien Lin, Li-Shing Chu, Ren-Shyan Liu. Radiolabeled nucleosides for predicting and monitoring the cancer therapeutic efficacy of chemdrugs. Curr Med Chem 2012; 19:3315-3324.
  17. Pei-Chia Chan, Chun-Yi Wu, Wen-Yi Chang, Mian M. Alauddin, Ren-Shyan Liu, Wuu-Jyh Lin, Fu-Du Chen, Chuan-Lin Chen, Hsin-Ell Wang. Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging. Nucl Med & Biol. 2011;38:987-995.  
  18. Ren-Shyan Liu, Ta-Kai Chou, Chih-Hsien Chang, Chun-Yi Wu, Chi-Wei Chang, Tsui-Jung Chang, Shih-Jen Wang, Wuu-Jyh Lin and Hsin-Ell Wang. Biodistribution, pharmacokinetics and PET imaging of 18F-FMISO, 18F-FDG, and 18F-FAc in a sarcoma- and inflammation-bearing mouse model. Nucl Med & Biol. 2009;36:305-12.
  19. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Ren-Shyan Liu, Mian M. Alauddin and Hsin-Ell Wang. Radiosynthesis of F-18 labeled cytidine analogue 2’-fluoro-5-iodo-1-b–D  -arabinofuranosylcytosine (18F-FIAC). Appl Radiat Isot. 2009;67:1362-1365.

Conference Abstracts

  1. Hsin-Hua Hsieh, Jia-Jia Lin, Ya-Wen Hsiao, Chu-Han Huang, Jiaqi Chen, Chun-Yi Wu. Theranostic Boron-containing Gold Nanoparticles-encapsulated Biodegradable Polymeric Matrix for Boron Neutron Capture Therapy. World Molecular Imaging Congress, Montreal, Canada, Sept 2019. (oral presentation)
  2. Yang-Yi Chen, Hsin-Hua Hsieh, Ching-Yu Hsiao, Hsin-Ell Wang, Chun-Yi Wu. Synthesis of 18F-2-(4-fluoro-2-(p-tolyloxy)phenyl)-1,2-dihydroisoquinolin-3(4H)-one (18F-TPQ) as a TSPO Ligand. World Molecular Imaging Congress, Seattle, USA, Sept 2018.
  3. Jia-Jia Lin, Li-An Chen, Chu-Han Huang, Jiaqi Chen, Chun-Yi Wu. Development of boron-containing gold nanoparticles for boron neutron capture therapy (BNCT). World Molecular Imaging Congress, Seattle, USA, Sept 2018.
  4. Jia-Jia Lin, Yang-Yi Chen, Wen-Yi Chang, Chun-Yi Wu. Development of theranostic boron-containing gold nanoparticles for boron neutron capture therapy (BNCT). World Molecular Imaging Congress, Philadelphia, USA, Sept 2017.
  5. Jia-Jia Lin, Yang-Yi Chen, Hsin-Hua Hsieh, An-Suei Yang, Chun-Yi Wu. Establish an imaging platform for screening anti-HER2 antibodies. World Molecular Imaging Congress, Philadelphia, USA, Sept 2017.
  6. Yang-Yi Chen, Jia-Jia Lin, Min-Ying Lin, Hsin-Ell Wang, Chun-Yi Wu. The feasibility of 18F-labeled paeonol derivative to detect neuroinflammation. World Molecular Imaging Congress, Philadelphia, USA, Sept 2017.
  7. Chun-Yi Wu, Pei-Chia Chan, Chi-Wei Chang, Feng-Yi Yang, Ren-Shyan Liu, Sang-Hue Yen, Hsin-Ell Wang. Monitoring the effect of HIFU on boron drug accumulation with 18F-FBPA-Fr microPET in a human head and neck cancer xenograft-bearing mouse model. 60th Annual Society of Nuclear Medicine Meeting in Vancouver, CA, June 2013.
  8. Chun-Yi Wu, Pei-Chia Chan, Ren-Shyan Liu, Wuu-Jyh Lin, Hsin-Ell Wang. Radiosynthesis and biological characterization studies of 18F-FEFAHA for imaging the activity of histone deacetylase. 59th Annual Society of Nuclear Medicine Meeting in Miami, USA, June 2012.
  9. Chun-Yi Wu, Chung-Hsien Ho, Ren-Shyan Liu, Chuan-Lin Chen, C. Allen Chang, Hsin-Ell Wang. Radiosynthesis and microPET imaging of 18F-fluoropropyl-b-D-glucoside for tumor detection via sodium-dependent glucose transporters. World Molecular Imaging Congress, San Diego, USA, Sept 2011.
  10. Chun-Yi Wu, Pei-Chia Chan, Ren-Shyan Liu, C. Allen Chang, Hsin-Ell Wang. Radiosynthesis and biological characterization studies of I-123 labeled iodosuberoylanilide hydroxamic acid (123I-ISAHA). 58th Annual Society of Nuclear Medicine Meeting in San Antonio, USA, June 2011.
  11. Chun-Yi Wu, Chih-Yuan Lin, Pei-Chia Chan, Ren-Shyan Liu, C. Allen Chang, Jenn-Tzong Chen, Wuu-Jyh Lin, Ming-Hsien Lin and Hsin-Ell Wang. Evaluation of 123/131I-IUdR as a SPECT probe in sarcoma- and lung carcinoma-bearing mouse models. World Molecular Imaging Congress, Kyoto, Japan, Sept 2010.
  12. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Hsin-Ell Wang, and Ren-Shyan Liu. Evaluation of 18F-clofarabine as a PET probe of deoxycytidine kinase in mouse and rat models of glioblastoma. 56th Annual Society of Nuclear Medicine Meeting in Toronto, USA, June 2009.
  13. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Ren-Shyan Liu, Mian M. Alauddin and Hsin-Ell. Radiosynthesis of F-18 labeled cytidine analogue 2’-fluoro-5-iodo-1- b-D  -arabinosylfuranose (18F-FIAC). Annual 6th International Conference on Radioisotopes, Seoul, Korea, May 2008.
  14. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Chi-Wei Chang, Ren-Shyan Liu and Hsin-Ell Wang. A comparative study of FEAU, FIAU and FIAC as HSV1-tk gene expression probes. Taipei International Symposium of Molecular Imaging, Taipei, Taiwan, Oct 2007.

Patents

NameCountryNo.InventorsAssignee
Synthetic Method and Automation Device for Fluorine-18-AcetateUSAUS 8007730B2Ming-Hsin Li, Hsin-Ell Wang, Chun-Yi Wu, Wuu-Jyh LinInstitute of Nuclear Energy Research, Longtan, Taoyuan, Taiwan

聯絡方式

Tel: +886-2-2826-7215 (Office)

Fax: +886-2-2820-1095

e-mail: chunyiwu@nycu.edu.tw